Final answer:
Maternal Indomethacin treatment is associated with adverse effects including constriction of the fetal ductus arteriosus, fetal renal impairment, oligohydramnios, pulmonary hypoplasia, and skeletal deformations.
Step-by-step explanation:
Maternal treatment with Indomethacin can be associated with various adverse fetal effects. Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that can cause constriction of the fetal ductus arteriosus, leading to compromised fetal circulation. Additionally, similar to other teratogens such as ACE inhibitors, Indomethacin can also contribute to fetal renal impairment and reduced amniotic fluid volume, known as oligohydramnios. This can result in further complications like pulmonary hypoplasia (underdeveloped lungs) and skeletal deformations, including limb contractures. It is important for pregnant women to discuss potential risks with their healthcare provider before taking medications like Indomethacin.