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What is true of *ACE Inhibitors* (Lisinopril) during pregnancy?

User Jmoneystl
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Final answer:

ACE inhibitors such as Lisinopril are dangerous during pregnancy as they can cause fetal renal failure, oligohydramnios, and subsequent developmental issues like pulmonary hypoplasia and limb contractures. These medications are thus contraindicated and other blood pressure treatments should be used.

Step-by-step explanation:

Angiotensin-converting enzyme (ACE) inhibitors, such as Lisinopril, are contraindicated during pregnancy due to their association with fetal harm. These medications, which are used to treat hypertension, block the conversion of angiotensin I to angiotensin II, thereby lowering blood pressure. However, during pregnancy, they can lead to fetal renal failure and oligohydramnios. This condition can in turn result in pulmonary hypoplasia, limb contractures, and cranial bone abnormalities in the fetus. Therefore, ACE inhibitors like Lisinopril are not recommended for use during pregnancy. Alternative blood pressure medications should be considered for pregnant individuals.

User DrGary
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