Question

Which alloantibody is most likely to be produced if a patient that has the Rh genotype of R1R1 is transfused with red blood cells that have an Rh genotype of R0R0?

a-Anti-D
b-Anti-C
c-Anti-c
d-Anti-E
e-Anti-e

Answer 1

In a patient with Rh genotype R1R1 transfused with R0R0 genotype red blood cells, the production of an anti-e antibody is most likely.

Step-by-step explanation:

The Rh genotype of R1R1 denotes the presence of Rh D and Rh C antigens, as R1 corresponds to the genetic code Dce. When a patient with Rh genotype R1R1 receives a transfusion with red blood cells of the Rh genotype R0R0, which corresponds to the genetic code cde, there is a likelihood of producing an alloantibody against the antigens that the patient lacks. In this case, the patient's immune system is sensitized to the Rh D antigen and already has anti-E, so the development of an anti-e antibody is likely since 'e' antigen is present in the transfused R0R0 cells and absent from the patient's R1R1 genotype.