Final answer:
Opioids affect the central nervous system, while nonopioid analgesics inhibit enzymes linked to pain at receptor sites.
Step-by-step explanation:
Opioids act primarily on the central nervous system and nonopioid analgesics act on the enzymes at the pain receptors sites. Opioid drugs work by attaching to receptors in the brain, spinal cord, and gastrointestinal tract, altering the perception of pain. They include medications derived from opium, such as morphine and codeine, as well as synthetic drugs like hydrocodone and oxycodone. Common side effects of opioids can include drowsiness, euphoria, and in higher doses, loss of consciousness. Nonopioid analgesics, such as aspirin, work by blocking COX enzymes that play a key role in pain and inflammation.