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By which action does colchicine (Colcrys) relieve symptoms of gout?

a. It inhibits the migration of leukocytes in the inflamed area.
b. It blocks reabsorption of uric acid.
c. It blocks prostaglandin release.
d. It inhibits uric acid synthesis.

1 Answer

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Final answer:

Colchicine relieves symptoms of gout by inhibiting the migration of leukocytes, which in turn decreases inflammation. Its action involves the inhibition of mitosis, leading to a reduced white blood cell count.

Step-by-step explanation:

Colchicine (Colcrys) is a medication used to relieve symptoms of gout, which is a form of arthritis characterized by the accumulation of uric acid crystals in the joints, causing intense pain. Colchicine provides relief by inhibiting the migration of leukocytes to the inflamed area, thereby decreasing inflammation. Inhibition of mitosis, which leads to a decreased white blood cell count, is the mechanism through which colchicine achieves this. While this action can be beneficial for reducing the painful inflammation associated with gout, it can also cause undesirable side effects such as a low white blood cell count.

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