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Uricosuric agents such as probenecid (Benemid) are used in the treatment of gout. What is the mechanism of action?

a. Retention of urate crystals in the body.
b. Inhibition of the reabsorption of uric acid in the body.
c. Promotion of uric acid removal in the ureters
d. An increased release of uric acid.

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Final answer:

Uricosuric agents like probenecid (Benemid) are used in the treatment of gout by inhibiting the reabsorption of uric acid in the body.

Step-by-step explanation:

Uricosuric agents such as probenecid (Benemid) are used in the treatment of gout. The mechanism of action involves inhibition of the reabsorption of uric acid in the body. Probenecid blocks the transporter proteins in the kidney responsible for reabsorbing uric acid from the urine back into the bloodstream. This prevents the uric acid from being recycled and increases its excretion in the urine, thereby decreasing the concentration of uric acid in the body.

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