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How does Danazol work (mechanism), what are its clinical uses, and what potential toxicities should be considered?

User TonyB
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Final answer:

Danazol is a synthetic androgen used in the treatment of endometriosis and hereditary angioedema. It suppresses hormone release from the pituitary gland and can cause masculinizing side effects and liver toxicity.

Step-by-step explanation:

Danazol is a synthetic androgen (male hormone) that works by suppressing the release of hormones from the pituitary gland in the brain, which in turn reduces the production of certain hormones in the ovaries and testes. It is primarily used in the treatment of endometriosis, a condition where tissue similar to the lining of the uterus grows outside of the uterus, causing pain and infertility. Danazol can also be used to treat hereditary angioedema, a rare genetic disorder that results in recurring episodes of swelling in various parts of the body.

Potential toxicities of Danazol include masculinizing side effects such as acne, voice deepening, and increased facial hair growth. It can also cause liver toxicity, and regular liver function tests are recommended while taking the medication. Other common side effects include weight gain, fluid retention, and mood changes.

User Job Martinez
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