Final answer:
The method for reversing the blockade of depolarizing neuromuscular blocking drugs is to inhibit the enzyme acetylcholinesterase (AChE).
Step-by-step explanation:
Reversing the blockade of depolarizing neuromuscular blocking drugs can be done by inhibiting the enzyme acetylcholinesterase (AChE). AChE degrades acetylcholine (ACh) in the synaptic cleft, preventing it from rebinding to its receptors and reopening the channels. By administering drugs that inhibit AChE, such as neostigmine or pyridostigmine, the blockade can be reversed and muscle contractions can be restored.