Final answer:
Bevacizumab is a monoclonal antibody drug that inhibits the activity of VEGF, which is involved in the growth of new blood vessels. Its clinical uses include the treatment of various types of cancer, and it may cause toxicities such as high blood pressure and bleeding.
Step-by-step explanation:
Bevacizumab is a monoclonal antibody drug that targets and inhibits the activity of vascular endothelial growth factor (VEGF), a protein involved in the growth and development of new blood vessels. By blocking VEGF, Bevacizumab prevents the formation of new blood vessels in tumors, which can inhibit tumor growth and block the supply of nutrients and oxygen to the tumor.
Bevacizumab is used in the treatment of several types of cancer, including colorectal cancer, lung cancer, kidney cancer, and certain types of brain tumors. It may be used alone or in combination with other chemotherapy drugs.
Potential toxicities of Bevacizumab can include high blood pressure, bleeding, blood clots, gastrointestinal perforation, impaired wound healing, and proteinuria (excess protein in the urine).