Final answer:
6-mercaptopurine (6-MP), azathioprine, and 6-thioguanine (6-TG) are commonly used in clinical practice for various purposes, including the treatment of leukemia, inflammatory bowel disease, and autoimmune diseases.
Step-by-step explanation:
6-mercaptopurine (6-MP), azathioprine, and 6-thioguanine (6-TG) are commonly used in clinical practice for various purposes.
6-MP, a purine analog, inhibits the biosynthesis of adenine nucleotides, preventing the synthesis of DNA. It is used in the treatment of acute lymphoblastic leukemia and inflammatory bowel disease.
Azathioprine is converted to 6-MP in the body and also inhibits DNA synthesis. It is commonly used as an immunosuppressant in organ transplantation and for the treatment of autoimmune diseases such as rheumatoid arthritis.
6-TG, another purine analog, also interferes with DNA synthesis and is used in the treatment of acute myeloid leukemia.