Final answer:
Glitazones or thiazolidinediones work by binding to insulin receptors in the body, specifically the PPARγ receptors, which activate genes involved in glucose and lipid metabolism. This leads to increased insulin sensitivity and improved glucose utilization.
Step-by-step explanation:
The mechanism of action of glitazones or thiazolidinediones involves their interaction with the insulin receptors in the body. Glitazones work by binding to a group of receptors called the peroxisome proliferator-activated receptors gamma (PPARγ). When glitazones attach to these receptors, they activate certain genes that are involved in the regulation of glucose and lipid metabolism. This activation leads to increased insulin sensitivity and enhanced glucose utilization in the body, thereby helping to lower blood glucose levels.