Final answer:
True, a south cardinal buoy indicates that the safest water is to the south of the buoy.
Step-by-step explanation:
The question 'Cardinal Buoy South: Indicates that the safest water is to the south' can be answered as 'True'. In navigational systems, a cardinal buoy is used to indicate where the safest and deepest water is located in relation to the buoy itself. A south cardinal buoy indicates that the safest water lies to the south of the buoy. Mariners should navigate accordingly to ensure safe passage.