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Location of beta-oxidation Short/medium chain FA?

A) Mitochondrial matrix
B) Peroxisomes
C) Cytosol
D) Endoplasmic reticulum

1 Answer

3 votes

Final answer:

Beta-oxidation of short/medium chain fatty acids primarily occurs in the mitochondrial matrix, where fatty acids are converted into acetyl-CoA and then used in the Krebs cycle to produce ATP. Option A is correct

Step-by-step explanation:

The process of beta-oxidation involves the breakdown of fatty acids and takes place primarily in the mitochondrial matrix. Fatty acids are initially converted into fatty acyl-CoA molecules in the cytoplasm. These molecules are then attached to carnitine, creating a fatty acyl carnitine molecule that is transported across the mitochondrial membrane.

Once inside the mitochondrial matrix, fatty acylcarnitine is converted back into fatty acyl-CoA and, subsequently, into acetyl-CoA. This acetyl-CoA then enters the Krebs cycle, contributing to ATP production. Peroxisomes also contribute to fatty acid oxidation, particularly with very long-chain fatty acids, which are shortened before they are handed off to the mitochondria for further beta-oxidation.

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