Final answer:
The ODB program will reimburse for a higher-cost interchangeable product when "no substitution" is indicated by the prescriber on the prescription, typically for reasons related to patient's clinical needs.
Step-by-step explanation:
The Ontario Drug Benefit (ODB) program will provide reimbursement for a higher-cost interchangeable product when the prescriber indicates "no substitution" on the prescription. This means that the prescriber has specified on a prescription that the brand name drug, rather than a generic or lower-cost alternative, must be dispensed to the patient. The indication of "no substitution" is usually made for clinical reasons where the prescriber deems it necessary for the patient to receive a specific brand due to concerns about effectiveness or potential reactions to different formulations.