Question

What happens if two identical vesicles must fuse, what happens with the SNAREs? (EX. to form the cis-golgi?)

A. They align perfectly
B. They misalign
C. They undergo conformational change
D. They disassemble

Answer 1

In the fusion of two identical vesicles, SNARE proteins undergo a conformational change to facilitate membrane fusion, and after fusion, the SNARE complex is disassembled for recycling. Option C is correct.

Step-by-step explanation:

When two identical vesicles fuse, the SNARE proteins undergo a conformational change. This is a crucial step that facilitates the merging of the vesicle membranes. V-SNARE proteins on the vesicles bind to complementary T-SNARE proteins on the target membrane, such as the cis-Golgi, to initiate fusion.

The SNAREs twist around each other to pull the membranes together, allowing them to eventually fuse. Upon successful fusion, the SNARE complex is often disassembled by other cellular proteins so that the SNAREs can be recycled and used for further vesicle fusion events.