Question

What 3 topological characteristics of a multi-pass TM membrane can be predicted from its sequence?

A) Number of helices, loop length, extracellular domains
B) Hydrophobicity, charge distribution, glycosylation sites
C) Signal sequence length, amino acid composition, molecular weight
D) N-terminal orientation, C-terminal orientation, loop topology

Answer 1

The correct option is A .The number of helices, extracellular domains, and loop topology are the three topological characteristics of a multi-pass TM membrane that can be predicted from its amino acid .

Step-by-step explanation:

The topological characteristics of a multi-pass transmembrane (TM) protein that can be predicted from its amino acid sequence are: 1) Number of helices: Determined by identifying hydrophobic .

alpha-helical domains which are typical for membrane-spanning regions. 2) Extracellular domains: These can be predicted based on the orientation of how the helices insert into the membrane.

influenced by N-terminal signal sequences and stop-transfer sequences. 3) Loop topology: The length and orientation of loops connecting transmembrane helices can be inferred.

which helps predict the overall topology of the protein within the lipid bilayer.