Final answer:
The correct pathway from the plasma membrane to a lysosome is 'Plasma membrane to endosome to lysosome', where materials are first internalized into endosomes and then delivered to lysosomes, either by endosome maturation into a lysosome or by fusion with an existing lysosome.
Step-by-step explanation:
The pathway from the plasma membrane (PM) to a lysosome involves multiple steps within the cell's endomembrane system. Initially, materials are internalized at the plasma membrane through a process known as endocytosis, which forms endosomes. These endosomes then often mature into lysosomes or fuse with pre-existing lysosomes, completing the final step in the delivery of materials from the PM to the lysosome.
Breaking down the options given, and considering the information, the correct answer is C: Plasma membrane to endosome to lysosome. This pathway starts with the internalization of materials into endosomes through the plasma membrane. The endosomes then transport these materials, ultimately either maturing into lysosomes or fusing with existing lysosomes, which contain enzymes capable of breaking down the materials.