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What is the function of the RNase domain on IRE1?

A) Activates PERK
B) Cleaves XBP1 mRNA
C) Induces ATF6 phosphorylation
D) Inhibits eIF2alpha

1 Answer

3 votes

Final answer:

The RNase domain on IRE1 cleaves XBP1 mRNA as a part of the Unfolded Protein Response to help restore normal cell function when misfolded proteins accumulate.

Step-by-step explanation:

The function of the RNase domain on IRE1 is to cleave XBP1 mRNA. This is a critical process in the Unfolded Protein Response (UPR) pathway within the cell. When misfolded proteins accumulate in the endoplasmic reticulum (ER), IRE1 is activated and the RNase domain cleaves a specific intron from the XBP1 mRNA. This cleavage event is unconventional, as it does not occur at the standard splice sites, and results in a frame-shift that produces a potent transcription factor, XBP1s, which can then go on to upregulate UPR target genes that help to restore normal function to the cell.

User Ralph Bergmann
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