Final answer:
Mitochondria and peroxisomes are the two organelles not in the secretory pathway; they have unique protein directing tags that guide pre-folded proteins imported from the cytosol.
Step-by-step explanation:
The organelles that are not in the secretory pathway but have unique protein directing tags are mitochondria and peroxisomes. The primary role of the secretory pathway is to process and package proteins and lipids and it includes the endoplasmic reticulum, Golgi apparatus, lysosomes, and vesicles. Mitochondria, which are often referred to as the powerhouses of the cell, contain their own DNA and ribosomes and are believed to have arisen from an endosymbiotic event. Peroxisomes are also not part of the secretory pathway; they contain enzymes that break down fatty acids and detoxify certain chemicals. These organelles import their proteins pre-folded from the cytosol, and the proteins contain specific targeting sequences that guide them to the organelle where they function.