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Why may a protein have multiple TM helices?

A) Increased stability in the membrane
B) Enhanced binding to extracellular ligands
C) Facilitation of cytoplasmic signaling
D) Promotion of nuclear transport

1 Answer

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Final answer:

Proteins may have multiple TM helices to increase stability in the membrane, form channels for ion gating important in nerve and muscle function, and act as carrier proteins for specific substances, enabling crucial cellular processes.

Step-by-step explanation:

A protein may have multiple transmembrane (TM) helices for several functional reasons, including:

  • Increased stability in the membrane.
  • Formation of channels or gates through the membrane, as seen in gated channels for ions like sodium, potassium, and calcium, which are crucial for processes such as electrical signaling in nerve cells or muscle contraction.
  • Carrier protein activity, where the shape of the protein changes to move substances across the membrane, with each carrier protein being specific for a single substance.

These multiple helices can enhance the protein's ability to interact with other cellular components or substrates, facilitating vital cellular functions such as signaling, transport, and maintaining the structural integrity of the cell membrane.

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