Question

When do modifications occur and what is the native state of a protein?

A) After protein folding; denatured
B) Before protein synthesis; unfolded
C) During protein degradation; misfolded
D) After protein synthesis; native and functional

Answer 1

Modifications to proteins occur after protein synthesis, resulting in a functional native state. The folding process is critical as it determines the protein's structure and function, although denaturation can sometimes reverse this process. The correct answer is (D).

Step-by-step explanation:

The native state of a protein refers to its functional, three-dimensional structure after it has been properly folded. Protein modifications typically occur after protein synthesis; this is when the protein has been completely made and is in its functional form. After protein synthesis; native and functional. The folding process allows the protein to achieve its secondary, tertiary, and potentially quaternary structures, which are necessary for its biological role. \

Misfolding can lead to dysfunction and diseases, while the primary structure remains intact during denaturation – a process that can unfold proteins due to changes in temperature, pH, or chemical exposure. However, denaturation can sometimes be reversible, allowing the protein to refold and regain functionality. Therefore, The correct answer is (D).