Final answer:
ACE inhibitors increase blood levels of potassium by blocking the production of angiotensin II, which in turn reduces the production of aldosterone that promotes potassium excretion in the kidneys.
Step-by-step explanation:
Angiotensin-Converting Enzyme (ACE) Inhibitors are commonly used in the treatment of hypertension or high blood pressure. ACE inhibitors work by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor that increases blood pressure. By inhibiting the production of angiotensin II, ACE inhibitors lead to decreased blood pressure.
The renin-angiotensin system involves the production of aldosterone, which increases the reabsorption of sodium and water by the kidneys. As a result of blocking the production of angiotensin II, ACE inhibitors indirectly lead to decreased sodium reabsorption. However, they also increase blood levels of potassium because aldosterone is responsible for promoting potassium excretion in the kidneys. When aldosterone production is reduced due to inhibition of angiotensin II, potassium excretion is decreased, resulting in higher blood levels of potassium.