Question

___, used in the treatment of depression are non-specific. They block the receptors for noradrenaline, histamine and ACh. What are the side effects?

a) SSRIs; Sexual dysfunction, Weight gain
b) Benzodiazepines; Sedation, Respiratory depression
c) MAOIs; Hypertensive crisis, Serotonin syndrome
d) TCAs; Dry mouth, Constipation

Answer 1

Tricyclic antidepressants (TCAs) block the receptors for noradrenaline, histamine, and ACh, and their side effects include dry mouth and constipation.

Step-by-step explanation:

TCAs, or tricyclic antidepressants, block the receptors for noradrenaline, histamine, and ACh. Their side effects include dry mouth and constipation. These side effects are due to the anticholinergic properties of TCAs, because they block the action of acetylcholine, a neurotransmitter that is involved in the regulation of saliva production and gastrointestinal motility.