Final answer:
Chronic use of ethanol does lead to rebound excitation, as cessation of use results in the overactivity of the central nervous system, causing withdrawal symptoms related to the body's adaptation to alcohol's depressive effects.
Step-by-step explanation:
True, chronic use of ethanol does lead to rebound excitation. When chronic alcohol consumption is stopped, the body experiences a variety of withdrawal symptoms as a result of the nervous system's hyperactive state, which was previously suppressed by alcohol's depressive effects. The body had adapted to the presence of ethanol by upregulating excitatory neurotransmitter systems and downregulating inhibitory systems. The removal of ethanol leads to an overactivity of the central nervous system, manifesting in symptoms like tremors, seizures, insomnia, and confusion due to increased glutamatergic activity, and can even cause toxicity and cell death.