Question

The following DNA sequence 5' TGCGATCC-3' is mutated to 5'-TGTGATCC-3'. This is an example of which type of mutation? Transition Transversion Tautomeric shift Insertion

The following DNA sequence 5' TGCGATCC-3' is mutated to 5'-TGTGATCC-3'. This is an example of which type of mutation?
Transition
Transversion
Tautomeric shift
Insertion

Answer 1

The mutation from 5' TGCGATCC-3' to 5'-TGTGATCC-3' is a transversion, which is a type of point mutation where one base is replaced by another of a different kind (a purine to a pyrimidine or vice versa).

Step-by-step explanation:

The original DNA sequence given is 5' TGCGATCC-3' and the mutated sequence is 5'-TGTGATCC-3'. This mutation is a change from a cytosine to a thymine which represents a type of mutation known as a transversion.

A transversion is a type of point mutation where a purine is replaced by a pyrimidine, or vice versa. In this case, a pyrimidine (cytosine) is replaced by another pyrimidine (thymine), which classifies it as a transversion.

A tautomeric shift refers to a temporary change in base structure, leading to incorrect base pairing during DNA replication. An insertion is the addition of an extra base pair into a DNA sequence. Therefore, the mutation from 5' TGCGATCC-3' to 5'-TGTGATCC-3' is specifically a transversion mutation.