Final answer:
During Spanish exploration and conquests in America, new diseases were introduced, leading to a significant loss of life among native populations. Spanish exploration and colonization did not end in the 15th century, but continued into the 16th century and beyond.
Step-by-step explanation:
During the Spanish exploration and conquests in America, the following statements are true:
- C) Introduction of new diseases: When the Spanish arrived in the Americas, they inadvertently brought diseases, such as smallpox, which greatly weakened and caused a horrific loss of life among the native populations.
- D) Spanish exploration did not end in the 15th century: Spain's exploration and colonization of the New World continued into the 16th century and beyond, establishing permanent settlements and a powerful hemispheric empire.
These two statements accurately reflect the impact of Spanish exploration and conquests in America.