Final answer:
The specific cause of the formation of the Columbian Exchange between 1450-1750 was exploration and colonization, which led to the exchange of plants, animals, diseases, and technologies between Europe and the Americas.
Step-by-step explanation:
The specific cause of the formation of the Columbian Exchange between 1450-1750 was A. Exploration and colonization.
During this period, European explorers such as Christopher Columbus embarked on voyages of exploration and colonized parts of the Americas. This led to the exchange of plants, animals, diseases, and technologies between Europe and the Americas, which is known as the Columbian Exchange.
Exploration and colonization allowed for the establishment of trading empires and the interaction of different peoples, resulting in a profound shift in the world view of Europeans and the creation of a new global economy.