The RNA sequence is CAC CUG UUU UCU GAA
The amino acid sequence is His Leu Phe Ser Glu.
The DNA sequence is complementary to the RNA sequence, so the RNA sequence can be transcribed from the DNA sequence by replacing each thymine (T) with uracil (U).
So, The mRNA codon for phenylalanine (Phe) is UUU, and the mRNA codon for serine (Ser) is UCU. The amino acid sequence of beta-globin is Histidine - Leucine - Phenylalanine - Serine - Glutamic acid. This sequence is the same for both hemoglobin A (HbA) and hemoglobin S (HbS).
Therefore, people with sickle cell disease have a mutation in the HBB gene that changes the codon for glutamic acid (Glu) to the codon for valine (Val).
see text below
Sickle cell is a disease where a person has abnormally shaped blood cells. The reason for the abnormal shape of blood lies in the underlying genetic code.
The sequence below shows a part of the genetic code for the HBB Gene. This gene provides the instructions for making a protein called beta-globin. The gene sequence is shown below. Use the sequence to create RNA and the sequence of amino acids. Polypeptide chain Bchain
a chain Acid Iran Hams Hemoglobin
DNA of HBA - hemoglobin in normal adults
DNA 3' to 5' GTG GAC TGA GGA CTT
RNA CAC CUG -------- -------- GAA
Amino acid His Leu -------- -------- --------