Final answer:
T-cell priming involves the direct binding of the T-cell receptor to the peptide:MHC complex presented by dendritic cells in lymphoid organs, triggering T-cell activation and proliferation.
Step-by-step explanation:
T-cell priming is a crucial stage in the adaptive immune response and occurs in the lymphoid organs, such as the spleen and lymph nodes.
A key feature of this process is the requirement for direct binding between the T-cell receptor (TCR) and the peptide: major histocompatibility complex (peptide: MHC) presented by dendritic cells.
This interaction, accompanied by costimulatory signals and the production of cytokines, leads to the activation, proliferation, and expansion of naive T-cells that then differentiate into effector T cells capable of addressing specific antigenic challenges.