Final answer:
The false statement about prototyping is that it is least useful when there is uncertainty about design requirements or solutions. Prototyping is actually very valuable in these situations to ensure each iteration better reflects user needs.
Step-by-step explanation:
The statement about prototyping that is not true is that "prototyping is least useful when there is some uncertainty about requirements or design solutions." In fact, prototyping is most useful in situations where there is uncertainty about requirements or design solutions. Prototyping allows for planned iteration where each version aims to more accurately reflect the users' requirements, replacing unplanned rework. The development of a prototype typically involves several steps, which may include: establishing design criteria and constraints, generating initial concepts, and iterative testing and refinement. Moreover, prototyping is indeed frequently used for designing an information system's end-user interface and in some instances, a prototype may even be adopted as the production version of a system after rigorous testing and evaluation.