Final answer:
The major theme of the story "The Tell-Tale Heart" is the effects of guilt on the human psyche.
Step-by-step explanation:
The theme in the story "The Tell-Tale Heart" is the effects of guilt on the human psyche. Throughout the story, the narrator experiences intense guilt and paranoia after committing a murder, which ultimately leads to his downfall. The theme of guilt is evident in the narrator's actions, thoughts, and the overall atmosphere of the story.