Question

Which of the following drug classes interact dangerously with Monoamine Oxidase Inhibitors (MAOI)?

1) Tricyclic antidepressants
2) Selective Serotonin reuptake inhibitors (SSRI)
3) Tetracyclic antidepressants
4) 5HT2 antagonists

Answer 1

Tricyclic antidepressants, Selective Serotonin reuptake inhibitors (SSRI), Tetracyclic antidepressants, and 5HT2 antagonists interact dangerously with Monoamine Oxidase Inhibitors (MAOI).

Step-by-step explanation:

The drug classes that interact dangerously with Monoamine Oxidase Inhibitors (MAOIs) are:

1. Tricyclic antidepressants: These drugs can cause a dangerous increase in the levels of serotonin and norepinephrine, leading to a life-threatening condition known as serotonin syndrome.
2. Selective Serotonin reuptake inhibitors (SSRI): When combined with MAOIs, SSRIs can also increase serotonin levels and potentially cause serotonin syndrome.
3. Tetracyclic antidepressants: These drugs have a similar mechanism of action to tricyclic antidepressants and can also interact dangerously with MAOIs.
4. 5HT2 antagonists: These drugs can enhance the effects of serotonin and can also increase the risk of serotonin syndrome when combined with MAOIs.