Final answer:
Imipramine, a tricyclic antidepressant, is the most dangerous drug in overdose among the options listed due to its lower lethal dose and severe effects on the heart and brain, compared to the other drugs mentioned.
Step-by-step explanation:
When comparing the danger of overdose between the mentioned drugs, Imipramine stands out as the most dangerous. Imipramine is a tricyclic antidepressant (TCA), and TCAs are known for their lethal overdose potential. Overdose of TCAs can lead to severe heart rhythm problems, seizures, and can be fatal even at relatively low doses above the therapeutic level.
On the other hand, Moclobemide is a reversible inhibitor of monoamine oxidase A (MAO-A) and, while overdoses can lead to serious side effects, it is generally considered less toxic than traditional MAOIs. Paroxetine and Sertraline are both Selective Serotonin Reuptake Inhibitors (SSRIs). SSRIs have a high toxic dose and are considered safer in overdose compared to TCAs and MAOIs. Nevertheless, an overdose of SSRIs can still lead to serious adverse effects, such as serotonin syndrome, which can be life-threatening if not treated promptly.
The most dangerous drug in overdose among the ones listed is Imipramine, a tricyclic antidepressant known for its high toxicity in such cases.