Final answer:
Histamine is the neurotransmitter that is not stored in preformed secretory granules. Neurotransmitters like acetylcholine, serotonin, and noradrenaline are stored in vesicles before release, unlike histamine.
Step-by-step explanation:
Acetylcholine (ACh), serotonin, and noradrenaline are all stored in preformed secretory granules prior to their release. ACh is known for its role in muscle contractions at the neuromuscular junction, serotonin is derived from tryptophan and is crucial in the serotonergic system, and noradrenaline functions within the adrenergic system affecting the fight or flight response.
Amino acids such as glutamate, GABA, and glycine play roles as neurotransmitters and have their own systems, but they are not the direct answer to the question. These amino acid neurotransmitters are typically cleared from the synaptic cleft through reuptake and can be repackaged and released again. However, the question specifically asks about compatibility with preformed secretory granules, which does not apply to histamine.