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Which of the following drugs reduce the clearance of lithium?

1) Paracetamol
2) Aspirin
3) Thiazide
4) Clozapine

User Dildeepak
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Final answer:

Thiazide diuretics are known to reduce the clearance of lithium, potentially causing lithium toxicity. Other drugs listed, including Paracetamol, Aspirin, and Clozapine, do not have the same effect on lithium clearance.

Step-by-step explanation:

Among the drugs listed, thiazide diuretics are known to reduce the clearance of lithium, leading to an increased risk of lithium toxicity. This interaction occurs because thiazides decrease the renal clearance of lithium, causing lithium to build up in the body. It is important for individuals taking lithium to be aware of this interaction and to consult with their healthcare provider regarding the use of thiazide diuretics or any other medications that may affect lithium levels.

As for Paracetamol, Aspirin, and Clozapine, these drugs do not significantly affect lithium clearance in a way that thiazides do. However, clozapine may have other interactions with lithium that require careful monitoring, but it does not reduce lithium clearance directly.

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