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Regarding neuromuscular junction blockers, which of the following statements is CORRECT?

1) Vecuronium is an isoquinolone derivative
2) Pancuronium causes histamine release
3) Gentamicin increases their efficacy
4) Gallamine is eliminated by the liver

1 Answer

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Final answer:

The statement that is correct regarding neuromuscular junction blockers is that gentamicin increases their efficacy by potentiating their effects.

Step-by-step explanation:

The correct statement regarding neuromuscular junction blockers is that gentamicin increases their efficacy. Neuromuscular junction blockers are drugs that inhibit the transmission of impulses between motor neurons and skeletal muscles. They act at the neuromuscular junction by preventing the neurotransmitter acetylcholine from binding to its receptor, leading to muscle relaxation and paralysis. Vecuronium, mentioned in statement 1, is not an isoquinolone derivative; it is a steroid derivative. Pancuronium, mentioned in statement 2, does indeed cause histamine release. Gallamine, mentioned in statement 4, is primarily excreted by the kidneys, not the liver. Antibiotics like gentamicin can potentiate the effect of neuromuscular blockers by interfering with neurotransmission at the neuromuscular junction.

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