Final answer:
Dantrolene treats malignant hyperthermia by decreasing calcium release from the sarcoplasmic reticulum, helping to relax the muscles and reduce hypermetabolism. Option 1 is correct.
Step-by-step explanation:
Dantrolene is used in the treatment of malignant hyperthermia, a life-threatening complication that can occur during or after the administration of certain general anesthetics or the muscle relaxant succinylcholine.
The mechanism of action of Dantrolene that best describes how it works in this situation is option 1: It decreases calcium release from the sarcoplasmic reticulum.
Malignant hyperthermia is characterized by a rapid increase in body temperature and severe muscle contractions due to excessive calcium release from the sarcoplasmic reticulum within muscle cells.
By reducing this calcium release, Dantrolene helps to relax the muscles and reduce the hypermetabolic state characteristic of malignant hyperthermia.
The best statement that describes the mechanism of action of Dantrolene in malignant hyperthermia is that it decreases calcium release from the sarcoplasmic reticulum.