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Regarding atracurium, which of the following statements is CORRECT?

1) It is not associated with histamine release
2) It has a longer duration of action than vecuronium
3) It is eliminated by non renal or liver dependant mechanisms
4) It is a steroid derivative

User Bpjoshi
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1 Answer

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Final answer:

The correct statement regarding atracurium is that it is eliminated by non renal or liver dependent mechanisms, known as Hofmann elimination and ester hydrolysis, which allows its use in patients with renal or hepatic impairment.

Step-by-step explanation:

The correct statement regarding atracurium is that it is eliminated by non renal or liver dependent mechanisms. Atracurium is a non-depolarizing neuromuscular blocker that works by competitively inhibiting the action of acetylcholine at the neuromuscular junction. Unlike other muscle relaxants that require the liver or kidneys for elimination, atracurium undergoes Hofmann elimination and ester hydrolysis, which are processes that do not depend on organ function. Therefore, it can be safely used in patients with renal or hepatic impairment.

Atracurium does cause histamine release, which can lead to side effects like flushing, hypotension, and tachycardia. It has a shorter duration of action compared to vecuronium, and it is not a steroid derivative; it is a benzylisoquinolinium compound.

User Foka
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