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What is Yolk Sac (endodermal sinus) Tumor?

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A Yolk Sac (endodermal sinus) Tumor is a rare, malignant germ cell tumor associated with elevated AFP levels in patients. It originates from cells that would normally form the yolk sac, which provides essential nourishment and blood circulation to the early embryo. This type of tumor can occur in both children and adults, frequently along the body's midline.

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A Yolk Sac (endodermal sinus) Tumor is a type of germ cell tumor typically found in children. It originates from cells that form the yolk sac of an embryo. In normal development, the yolk sac is a membranous sac attached to the embryo, formed by cells of the hypoblast. It provides nourishment to the early embryo and is a crucial component for primitive blood circulation and germ cell production. The yolk sac eventually contributes to the formation of the umbilical cord structure. In the context of cancer, a Yolk Sac Tumor is considered highly malignant and can be indicated by elevated levels of alpha-fetoprotein (AFP) in a patient. AFP is a protein that is normally produced by a developing fetus, and its elevated levels in cancer survivors can suggest a relapse or the presence of a Yolk Sac Tumor.

During implantation, the embryo embeds itself in the uterine endometrium, and the yolk sac functions to support the developing embryo until the placenta takes over in approximately the fourth week of development. The Yolk Sac Tumor is a rare form of cancer and can be found in both males and females, often presenting in the testicles or ovaries in adults and along the midline of the body in infants and young children.

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