Final answer:
Life-threatening adverse reactions of opioids like Fentanyl can include respiratory distress, severe hypotension leading to anaphylactic shock, and other fatal complications such as disseminated intravascular coagulation and central nervous system collapse.
Step-by-step explanation:
The life-threatening adverse reactions of opioids such as Fentanyl, Remifentanil, and Sufentanil include respiratory distress, hypotension (plummeting blood pressure), and anaphylactic shock. These medications can cause a severe allergic reaction resulting in difficulty breathing and a significant drop in blood pressure, which can lead to death if not immediately treated with epinephrine. Other dangerous effects can include fever, jaundice, disseminated intravascular coagulation, which may lead to kidney failure, blurred vision, drooping eyelids, difficulty swallowing, nausea, vomiting, and conditions that are often fatal like hemorrhaging in various organs and potential central nervous system collapse.
When exposed to high doses or in cases of overdose, the severity of these symptoms is greatly increased, potentially resulting in lethality, particularly if there is a malfunction of the small intestine and blood systems, or if the central nervous system collapses.