Question

___________ nonsurgical periodontal interventions targets the host's response to disease rather than the host's bacterial load as a way to reduce destructive collagenase activity.

Answer 1

Host-modulating therapies are nonsurgical periodontal interventions that target the host's response to disease, aiming to reduce destructive collagenase activity.

Step-by-step explanation:

Nonsurgical periodontal interventions that target the host's response to disease rather than the host's bacterial load to reduce destructive collagenase activity are known as host-modulating therapies. These therapies aim to modify the inflammatory response and promote tissue healing. Examples of host-modulating therapies include the use of nonsteroidal anti-inflammatory drugs (NSAIDs), subgingival antiseptics, and local delivery of antimicrobials such as doxycycline.

Answer 2

Host-modulation therapy in periodontal disease focuses on reducing collagenase activity to preserve periodontal ligaments, which are essential for tooth stability and are weakened by diseases like scurvy.

Step-by-step explanation:

Host-modulation therapy nonsurgical periodontal interventions target the host's response to disease rather than the host's bacterial load as a way to reduce destructive collagenase activity. The periodontal ligaments, which are crucial for anchoring teeth, are composed of collagen fibers. Diseases such as scurvy, which impede collagen production, can therefore weaken these ligaments, leading to tooth destabilization and potential loss. As collagenase is an enzyme that breaks down collagen, inhibiting it can help preserve the structure and integrity of the periodontal ligament, reducing damage from periodontal diseases like periodontitis.