Final answer:
The clinical presentation of angioinvasive aspergillosis mainly includes respiratory symptoms such as fever, cough, chest pain, and shortness of breath, and can have serious complications like pulmonary and brain hemorrhages.
Step-by-step explanation:
Clinical presentation of angioinvasive aspergillosis primarily involves symptoms associated with the respiratory system. The most common clinical manifestations include fever, cough, chest pain, and shortness of breath. As this type of aspergillosis progresses, it can lead to severe complications such as pulmonary hemorrhage, resulting in a bloody cough, and in disseminated cases, even brain hemorrhages, which can be fatal. In cases where it begins as primary cutaneous aspergillosis or secondary cutaneous aspergillosis following systemic dissemination, distinctive eschars may be present on the skin.
Diagnosis of angioinvasive aspergillosis often requires a combination of chest radiographs, microscopic examination of respiratory fluid samples, and tissue biopsy. Treatment typically includes intravenous antifungal agents like voriconazole or itraconazole. For allergic reactions associated with aspergillosis, corticosteroids may be utilized but are contraindicated in disseminated infections to avoid suppressing the immune system's protective response. For severe cases, especially in immunocompromised individuals, timely intervention is critical due to the high risk of mortality.