Final answer:
Ocular beta-blockers are contraindicated in children under 12 years old, pregnant women, and patients with asthma.
Step-by-step explanation:
Ocular beta-blockers are contraindicated in several populations:
- Children under 12 years old: Ocular beta-blockers have not been extensively studied in children under 12, so their safety and efficacy are unknown.
- Pregnant women: Ocular beta-blockers can potentially cross the placenta and affect the developing fetus, so they are generally not recommended during pregnancy.
- Patients with asthma: Beta-blockers can cause bronchoconstriction and worsen asthma symptoms, so they should be avoided in patients with asthma.
Therefore, the correct answer is option 4) All of the above.