Question

If a type 2 diabetic has been diagnosed with insulin resistance, which type of oral medication would be most appropriate?

1) Metformin
2) Sulfonylureas
3) Thiazolidinediones
4) DPP-4 inhibitors

Answer 1

For a type 2 diabetic diagnosed with insulin resistance, Metformin is generally the most appropriate oral medication due to its effectiveness in improving insulin sensitivity. Other medications like Sulfonylureas, Thiazolidinediones, and DPP-4 inhibitors act through different mechanisms and are considered based on individual patient needs.

Step-by-step explanation:

If a type 2 diabetic has been diagnosed with insulin resistance, the most appropriate type of oral medication would usually be Metformin. Metformin is known to decrease hepatic glucose production, improve insulin sensitivity, and enhance glucose uptake by muscles, directly targeting insulin resistance. Although other medications like Sulfonylureas, Thiazolidinediones, and DPP-4 inhibitors can also be used for the treatment of type 2 diabetes, they work by different mechanisms. Sulfonylureas stimulate insulin secretion from the pancreatic beta cells, but they do not directly improve insulin resistance and may cause hypoglycemia, as indicated by Arya's experience. Thiazolidinediones also improve insulin sensitivity but have a different profile of side effects. DPP-4 inhibitors work by prolonging the action of incretin hormones, which increases insulin release in response to meals and decreases the amount of glucose produced by the liver.