Final answer:
The Supremacy Clause is a provision in the Constitution that establishes it as the highest law, overriding state laws. It requires state judges to follow the Constitution even if it contradicts state laws. The Supreme Court interprets and enforces the Constitution in cases of conflict between federal and state laws.
Step-by-step explanation:
The Supremacy Clause is a constitutional provision found in Article VI of the Constitution that establishes the Constitution as the highest law of the land. It states that the Constitution, national laws, and national treaties form the supreme law, and that state judges must follow the Constitution even if it contradicts state laws. The Supreme Court plays a critical role in interpreting and enforcing the Constitution in cases of conflict between federal and state laws.