Final answer:
A CIII - CV prescription may be refilled up to five times within a six-month period as per DEA regulations, but state laws may vary.
Step-by-step explanation:
Regarding controlled substances regulated by the DEA, a prescription for a Schedule III (CIII), IV (CIV), or V (CV) medication may be refilled up to five times within a six-month period. After these five refills or once six months have passed, a new prescription is required. It's important to note that prescribing practices can vary by state and some states might have more restrictive laws on the number of refills, so it's always best to consult with a local pharmacy or the prescriber for clarification. Healthcare professionals must adhere to these federal and state regulations to ensure safe dispensing of controlled substances.