Final answer:
Tolerance to opioids from addictive use of opioids occurs when the body adapts to the drug's presence, requiring higher doses for the same effect. This can lead to physical dependence and withdrawal symptoms when the drug is stopped.
Step-by-step explanation:
Tolerance to opioids from addictive use of opioids comes from the body's ability to adapt to the presence of the drug and build up a resistance to its effects. When opioids are regularly used, the body makes adjustments to compensate for the drug's effects, which can result in the need for higher doses to achieve the same level of pain relief. This is known as tolerance.
Tolerance occurs at both the cellular level, where the body adjusts the number and sensitivity of opioid receptors, and at the neural level, where the brain adapts to the presence of opioids. Over time, this tolerance can lead to physical dependence and withdrawal symptoms when the drug is stopped. he latter can manifest as withdrawal symptoms such as anxiety and depression, underscoring the need for comprehensive rehabilitation efforts to address both the physical and mental health aspects of recovery.