Final answer:
Immediate reassessment of the patient with potential compartment syndrome after a tibial fracture reduction is crucial. Notify the attending physician and prepare for possible surgical intervention.
Step-by-step explanation:
A patient who is 12 hours post closed reduction of a tibial fracture and is experiencing unrelieved pain and an inability to move their toes despite pain medication should be assessed immediately for signs of compartment syndrome. This is a surgical emergency and warrants urgent attention by the healthcare team. Clinical intervention should involve the immediate notification of the attending physician, reassessment of the neurological and vascular status of the affected limb, and preparation for potential surgical intervention if compartment syndrome is confirmed.