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Which of the following events must occur first during hemostasis?

1) Platelet plug formation
2) Vascular spasm
3) Coagulation
4) Fibrinolysis

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Final answer:

The first event to occur during hemostasis is a vascular spasm, where the blood vessel's smooth muscles contract to limit blood flow, which precedes platelet plug formation, coagulation, and fibrinolysis.

Step-by-step explanation:

The process of hemostasis consists of several key events that occur when a blood vessel is injured. The first event that must occur is a vascular spasm. During a vascular spasm, the smooth muscle in the vessel walls contracts to reduce the flow of blood. This is followed by the formation of a platelet plug, which temporarily seals the injury. Subsequently, coagulation occurs, forming a blood clot that consists of a meshwork of fibrin, platelets, and blood cells, thereby providing a more permanent solution to the breach in the vessel wall. Finally, fibrinolysis takes place, which is the process that breaks down the clot after the vessel has healed. Therefore, the correct answer to which event occurs first during hemostasis is vascular spasm.

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