Final answer:
False, Prostaglandin analogs are not primarily used to reduce irritation upon topical application; rather, they can induce labor or treat glaucoma and their mechanism may involve sensitization to pain or inflammation rather than irritation reduction.
Step-by-step explanation:
The statement that the mechanism of prostaglandin analogs helps to reduce irritation upon topical administration is false. Prostaglandins are known for their role in the inflammatory process, inducing smooth muscle contraction, and sensitizing nerves to pain. They are synthesized from arachidonic acid using enzymes like cyclooxygenase and are involved in various physiological activities, including affecting blood vessel dilation and constriction, uterine contractions, and contributing to the sensation of pain. Drugs like aspirin and ibuprofen, classified as nonsteroidal anti-inflammatory drugs (NSAIDs), work by inhibiting prostaglandin synthesis, thereby reducing inflammation and pain. Although prostaglandin analogs have therapeutic uses, their role is not typically to reduce irritation upon topical application, but rather they can have applications such as inducing labor or treating glaucoma.